Diagnostic accuracy extraction and synthesis

Combine paired test accuracy measures

Record TP, FP, FN and TN separately in the extraction table. Use separate rows for thresholds and retain their dependence in the analysis. The sensitivity/specificity equation is a statistical specification, not an assumption node.

Flow diagram

Steps

Define test and clinical role

Specify intended use, target condition, index test and reference standard.

Extract paired accuracy data

Record true/false positives and negatives, thresholds and study populations.

Resolve incomplete test results

Prespecify indeterminate results, partial verification and missing cells.

Choose justified synthesis model

Consider bivariate or HSROC methods according to thresholds, questions and evidence.

Plan paired outputs and diagnostics

Present sensitivity and specificity jointly with uncertainty and threshold context.