Prediction performance and usefulness

Assess calibration discrimination and utility

Calibration concerns agreement between predicted probabilities and observed frequencies; discrimination concerns ranking. Report both with uncertainty. Decision utility depends on plausible thresholds and consequences, not only a high area under the curve.

Flow diagram

Prediction performance and usefulnessF1.S1Define performance targetsF1.S2Assess calibrationF1.S3Assess discrimination and overallerrorF1.S4Assess clinical utilityF1.S5Assess subgroups and uncertaintyF1.N1Performance assessment planDomainMetric or plotHorizonInterval methodInterpretationCalibrationDiscriminationOverall errorClinicalutilitySubgroupsF1.N2Assumptions and rationaleF1.N3Method and protocol evidenceF1.S0 Start flowPrediction performance and usefulnessF1.S999 End flowEnd flow

Steps

Define performance targets

Choose measures appropriate to outcome type and prediction horizon.

Assess calibration

Plan calibration plots, intercept/slope or outcome-appropriate calibration measures.

Assess discrimination and overall error

Specify discrimination, scoring rules and censoring-aware methods where needed.

Assess clinical utility

Specify decision thresholds, consequences and net-benefit analysis only where applicable.

Assess subgroups and uncertainty

Prespecify subgroup evaluations, precision and limitations.

Prediction performance and usefulness

End flow

Tables and supporting information

Performance assessment plan

Performance assessment planDomainMetric or plotHorizonInterval methodInterpretationCalibrationDiscriminationOverall errorClinicalutilitySubgroups

Specify measures before analysis; leave estimates empty.

Assumptions and rationale

Good discrimination does not imply calibration or clinical benefit. Account for censoring when evaluating time-to-event predictions.

Method and protocol evidence

Attach the protocol, methodological sources and versioned software specification supporting these decisions. Record citations and provenance; do not enter participant identifiers.

Sources