Evidence synthesis

Flows for this purpose

• Search and study selection

  Identify and screen eligible studies

• Data extraction and synthesis

  Prepare and combine study estimates

• Bias, robustness and certainty

  Assess trustworthiness of findings

• Extraction and structured synthesis

  Group and summarize eligible evidence

• Bias and evidence certainty

  Assess limitations and confidence

• Scoping search and source selection

  Identify relevant evidence sources

• Scoping data charting

  Extract consistent source characteristics

• Scoping evidence mapping

  Organize findings and research gaps

• Extraction and evidence network definition

  Define treatments and comparison geometry

• Network synthesis specification

  Specify direct and indirect comparisons

• Network coherence, bias and certainty

  Assess assumptions and evidence confidence

• Study identification and participant-data access

  Track studies and data availability

• Participant-data synthesis specification

  Model participants within study structures

• Participant-data bias, robustness and certainty

  Assess availability and analytical assumptions

• Diagnostic accuracy extraction and synthesis

  Combine paired test accuracy measures

• Diagnostic review bias and applicability

  Assess trustworthiness across clinical settings