Platform simulations and sample-size scenarios

Evaluate changing platform operating characteristics

Assess changing arms, eligibility, accrual and calendar trends jointly. Shared controls and any borrowing affect the operating characteristics of individual comparisons and claim families.

Flow diagram

Steps

Define candidate platform configurations

Specify cohorts, arm-entry patterns, controls and allocation rules.

Vary treatment and time scenarios

Include null/effective arms, changing standard care and calendar drift.

Simulate eligibility and operations

Model overlapping comparisons, accrual, delayed outcomes and arm closure.

Assess claim-specific performance

Evaluate error, power, bias, coverage and resource use across comparisons.

Document reproducibility and limitations

Record code versions, Monte Carlo precision and scenario coverage.