Within-person incidence analysis

Specify incidence contrasts and adjustments

Conditioning within people removes factors constant during observation, not time-varying confounding. Use a model with interval duration and appropriate age or seasonal structure; pooled event proportions do not reproduce SCCS.

Flow diagram

Within-person incidence analysisF1.S1Define within-person incidencecontrastF1.S2Select conditional count modelF1.S3Adjust time-varying effectsF1.S4Handle recurrence and dependenceF1.S5Specify estimation and checksF1.N1Within-person model planContrastRisk windowTime adjustmentOffsetEventdependencePrimary riskperiodSecondaryperiodSensitivityF1.N2Assumptions and rationaleF1.N3Method and protocol evidenceF1.N4Conditional rate model notationNᵢⱼ is the event count and Tᵢⱼ the durationin person i’s interval j. X indicates a riskperiod; Z describes time-varying factors.Conditioning on each person’s total removesthe person-specific αᵢ; exp(β) is therelative incidence for the specifiedcontrast. Do not estimate the SCCS effect bysimply pooling risk-period and baselinecounts across people. Standard modelassumptions about event-dependent exposure,observation and recurrence requireassessment; extensions must match theviolation.F1.S0 Start flowWithin-person incidence analysisF1.S999 End flowEnd flow

Steps

Define within-person incidence contrast

Specify risk periods relative to baseline and event definition.

Select conditional count model

Specify a conditional event-count model, conditioning on each person’s total and including interval-duration offsets. Choose the SCCS variant for the exposure and observation process; do not compare pooled counts alone.

Adjust time-varying effects

Prespecify age, season and calendar-time structure.

Handle recurrence and dependence

Justify event-independence assumptions or an appropriate extension.

Specify estimation and checks

Record uncertainty, sparse intervals and model diagnostics.

Within-person incidence analysis

End flow

Tables and supporting information

Within-person model plan

Within-person model planContrastRisk windowTime adjustmentOffsetEventdependencePrimary riskperiodSecondaryperiodSensitivity

Preserve interval duration and conditional person structure.

Assumptions and rationale

Stable personal characteristics are controlled by design, but event-dependent observation or exposure requires additional assumptions.

Method and protocol evidence

Attach the protocol, methodological sources and versioned software specification supporting these decisions. Record citations and provenance; do not enter participant identifiers.

Conditional rate model notation

Nᵢⱼ is the event count and Tᵢⱼ the duration in person i’s interval j. X indicates a risk period; Z describes time-varying factors. Conditioning on each person’s total removes the person-specific αᵢ; exp(β) is the relative incidence for the specified contrast. Do not estimate the SCCS effect by simply pooling risk-period and baseline counts across people. Standard model assumptions about event-dependent exposure, observation and recurrence require assessment; extensions must match the violation.

Sources