Crossover recruitment and sequence allocation

Assign participants to treatment sequences

Randomize treatment sequences, retaining participant assignment even when periods are missed. Treatment order and masking procedures should be documented independently.

Flow diagram

Crossover recruitment and sequence allocationF1.S1Assess crossover suitabilityF1.S2Recruit and assess baselineF1.S3Randomize treatment sequenceF1.S4Assign period schedulesF1.S5Track sequence dispositionF1.N1Sequence allocation registerSequenceTreatment orderAllocation ruleConcealmentStratificationSequence ASequence BF1.N2Assumptions and rationaleF1.N3Method and protocol evidenceF1.S0 Start flowCrossover recruitment and sequenceallocationF1.S999 End flowEnd flow

Steps

Assess crossover suitability

Justify stable condition, reversible effects and feasible follow-up across periods.

Recruit and assess baseline

Document consent, eligibility and pre-period assessments.

Randomize treatment sequence

Prespecify sequences, allocation ratios, concealment and stratification.

Assign period schedules

Link each sequence to treatment order, duration and washout.

Track sequence disposition

Record receipt, withdrawals and deviations by sequence and period.

Crossover recruitment and sequence allocation

End flow

Tables and supporting information

Sequence allocation register

Sequence allocation registerSequenceTreatment orderAllocation ruleConcealmentStratificationSequence ASequence B

A/B are editable sequence labels, not assumed treatment effects or fixed sample sizes.

Assumptions and rationale

Randomization assigns sequences, not independent participants to every period; preserve within-participant structure.

Method and protocol evidence

Attach the protocol, methodological sources and versioned software specification supporting these decisions. Record citations and provenance; do not enter participant identifiers.

Sources